ABSTRACT
Diabetes is a long-term medical condition in which the body has difficulty converting food into energy. High blood glucose levels are produced by poor glucose management, which alters the overall metabolic process of the body. The accumulation of abnormal (excess) blood glucose and the inability to metabolize plasma glucose causes lethal damage to the body's major organs or organ systems such as heart disease, nephropathy, retinal degeneration, sensory loss, and even premature death. Despite the administration of long-term medications, available diabetes mellitus therapy is unable to cure and unable to prevent patients from key organ damage. Diabetics have a significant financial burden, in addition to drug-drug interactions. A tremendous amount of data and proof has been amassed, proving medicinal plants' enormous potential. Plants are a naturally occurring source of therapeutic strategy for mankind. In accordance with the literature review, people who have metabolic syndrome are more likely to contract COVID-19. To overcome pandemics, we need efficient and effective herbal management. Kabasurakudineer is a polyherbal formulation that is gaining acceptance in the medical world. It may have a synergistic impact that is advantageous in the therapy of metabolic illnesses such as diabetes. Type 2 diabetes is expected to affect 640 million people by 2040, with 70% of those affected being hypertensive and predisposed to obesity and dyslipidemia. © 2023, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
ABSTRACT
Background: Novel coronavirus (COVID-19) is an infectious disease which causes the outbreak as a pandemic and reiterated the call for countries to take immediate actions and proportion response to treat, detect and cut back transmission to save lots of people's lives. Several targeting specific functional proteins and ligands against coronavirus have been reported to prevent replication of virus RNA. Aim(s): The study was aimed to targetthe interleukin-6 protein, that may further block the binding of the virus to human cell receptor and signal transduction which activate the intracellular JAK-MAPK (Janus Kinase\Mitogenactivated protein kinase) and JAK- STAT3 (Janus Kinase/Signal Transducer and Activator of Transcription) signaling pathways. Method(s): In this study, we selected 36 reported compounds and 2 standard anti-HIV drugs such as Abacavir and Hydroxychloroquine for the inhibition of IL-6 protein. It has been reportable with their antiviral efficacies against alternative virus-infected diseases. Molecular docking analyses were performed to identify the best affinity compound against IL-6. Result(s): Among 38 reported compounds, gallic acid and luteolin are the best binding affinity against Interleukin-6 protein. Conclusion(s): Therefore, the results suggest that gallic acid and luteolin has a potential inhibitory function against IL-6 protein, which inhibits the interaction and signal transduction of the virus with the host cell and it provide a potential lead molecule for the development of a new drug against COVID-19disease. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.